Trial | Enrollment/follow-up | Number of patients | Ischemic/non-ischemic CMP | Entry criteria | Medical therapies? | Outcomes with ICD |
Ischemic CMP (late post-MI) trials | ||||||
MADIT-I | 1991 to 1996 Mean follow-up 27 months | 196 | 100%/0% |
|
| Total mortality: HR 0.46 (95% CI 0.26-0.82) compared with conventional medical therapy alone |
MUSTT | 1990 to 1996 Mean follow-up 39 months | 704 | 100%/0% |
|
| SCA or death from arrhythmia: RR 0.24 (95% CI 0.13-0.45) for ICD versus no ICD |
CABG-Patch | 1993 to 1996 Mean follow-up 32 months | 900 | 100%/0% |
|
| Death from any cause: HR 1.07 (95% CI 0.81-1.42) ICD versus control* |
MADIT-II | 1997 to 2001 Mean follow-up 20 months | 1232 | 100%/0% |
|
| Total mortality: HR 0.65 (95% CI 0.51-0.93) compared with conventional medical therapy alone |
Ischemic CMP (early post-MI) trials | ||||||
DINAMIT | 1998 to 2003 Mean follow-up 30 months | 674 | 100%/0% |
|
| Total mortality: HR 1.08 (95% CI 0.76-1.55), ICD versus control group |
IRIS | 1999 to 2007 Mean follow-up 37 months | 898 | 100%/0% |
|
| Total mortality: HR 1.04 (95% CI 0.81-1.35) ICD versus control group |
Combined ischemic and nonischemic CMP trial | ||||||
SCD-HeFT | 1997 to 2003 Mean follow-up 45 months | 2521 | 52%/48% |
|
| Total mortality: HR 0.77 (95% CI 0.62-0.96) compared with conventional medical therapy alone |
Nonischemic CMP trials | ||||||
DEFINITE | 1998 to 2003 Mean follow-up 29 months | 458 | 0%/100% |
|
| Total mortality: HR 0.65 (95% CI 0.4-1.06) compared with conventional medical therapy alone |
COMPANION | 2000 to 2002 Median follow-up of 16 months | 1520 | 55%/45% |
|
| Combined HF death or HF hospitalization: HR 0.68 (95% CI 0.68-0.95) for CRT versus medical therapy alone |
DANISH | 2008 to 2014 Mean follow-up 68 months | 1114 | 0%/100% |
|
| Total mortality: HR 0.87 (95% CI 0.68-1.12) compared with conventional HF therapy alone |
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