Clinical indications for initiation of therapy |
Recurrent fever, night sweats, weight loss, fatigue |
Hyperviscosity |
Lymphadenopathy that is either symptomatic or bulky (≥5 cm in maximum diameter) |
Symptomatic hepatomegaly and/or splenomegaly |
Symptomatic organomegaly and/or organ or tissue infiltration |
Peripheral neuropathy due to WM |
Laboratory indications for initiation of therapy |
Symptomatic cryoglobulinemia |
Cold agglutinin anemia |
Immune hemolytic anemia and/or thrombocytopenia |
Nephropathy related to WM |
Amyloidosis related to WM |
Hemoglobin ≤10 g/dL |
Platelet count <100 x 109/L |
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