Site: | MSKCC[1] | UCSF[2] | MDACC[3] | UF[4] | Ghent University[5] | UCLA and Geneva Switzerland[6] | UFHPTI[7] |
Year | 2007 | 2007 | 2008 | 2009 | 2012 | 2012 | 2016 |
Number of patients | 85 | 127 | 68 | 109 | 130 | 220 | 84 |
Patients with nasal cavity tumors (%) | 28 | 28 | 100 | 63 | 24 | 30 | 80 |
Stage (%) | |||||||
T1-T2 | 12 | 13 | 60 | 39 | 30 | 34 | 6 |
T3-T4 | 81 | 87 | 34 | 61 | 62 | 65 | 94 |
Tx | – | – | 6 | – | 8 | – | – |
Node positive | 7 | 9 | 9 | 10 | 3 | 2 | 9 |
Recurrent | 7 | – | – | – | – | – | 8 |
Histology (%) | |||||||
Squamous cell | 49 | 65 | 66 | 29 | 18 | 57 | 26 |
Adenoid cystic | 13 | 22 | 18 | 15 | 4 | 16 | 17 |
Adenocarcinoma | – | 13 | 12 | 8 | 63 | 11 | 10 |
Sarcoma | 11 | – | – | – | – | – | – |
Sinonasal undifferentiated carcinoma | – | – | 4 | 13 | 6 | 14 | 8 |
Olfactory neuroblastoma | 8 | – | – | 20 | 8 | – | 27 |
Other | 20 | – | – | 15 | 1 | 2 | 12 |
Treatment (%) | |||||||
RT alone | – | 16 | 47 | 52 | 22 | 28 | 13 |
Preoperative RT | – | 7 | 4 | 7 | – | – | – |
Postoperative RT | 100 | 77 | 49 | 41 | 78 | 52 | 87 |
Surgery without RT | – | – | – | – | – | 20 | – |
Median RT dose | 63 Gy | RT alone, 66 Gy; Post-op RT, 63 Gy | RT alone, 65 Gy; Post-op RT, 58 Gy | RT alone, 70 Gy; Post-op RT, 64.8 Gy | 70 Gy | 73.8 Gy (RBE) protons | |
Five-year local control (%) | 62 | 62 | 86 | 63 | 59 | 57 | 83 (three years) |
Five-year regional control (%) | 87 | – | 92 | 91 | – | – | 94 (three years) |
Five-year disease-free survival (%) | 55 | 54 | 86 | – | 43 | – | 73 (three years) |
Five-year overall survival (%) | 67 | 52 | 82 | 55 | 64 | 63 | 63 (three years) |
Notes | Worse outcomes for squamous cell carcinoma, cribriform plate or orbit invasion, and positive nodes. | 16% of postoperative RT patients had gross residual disease; 15% of all patients received chemotherapy. GTR improved local control compared with STR (65 versus 44%). | Worse outcomes for nonsquamous cell histologies and T3-4 tumors. | 19% distant metastasis rate; 30% severe complications rate. Outcomes significantly improved with post-op RT compared with RT alone. | Only two regional failures. Intensity-modulated RT improved outcomes. | Only 3% of patients failed in nodes. Worse prognosis in nonnasal cavity primaries, squamous cell, and undifferentiated histologies, as well as advanced T stage. | 90% local control in patients without gross disease. 24% grade 3 or worse toxicity. |
Do you want to add Medilib to your home screen?