Methotrexate (MTX) regimens* | Primary remission rates (%) |
1) MTX five-day regimen: 0.3 to 0.5 mg/kg IV or IM daily for five days every two weeks (maximum 25 mg per dose) | 87 to 93 |
2) MTX weekly regimen: 30 to 50 mg/m2 IM weekly | 49 to 74 |
3) MTX-Leucovorin¶ eight-day regimen: | 74 to 90 |
MTX 1 mg/kg IM or IV on days 1, 3, 5, and 7 | |
Leucovorin¶ 15 mg orally on days 2, 4, 6, and 8 given 24 hours after each MTX dose | |
4) High-dose IV MTX-Leucovorin¶ | 69 to 90 |
MTX 100 mg/m2 IV over 30 minutes followed by | |
MTX 200 mg/m2 IV infusion over 12 hours | |
Leucovorin¶ 15 mg every 12 hours in six doses IM or orally beginning 24 hours after starting MTX | |
Dactinomycin regimens (Vesicant: If administered peripherally, give through free-flowing IV) | |
1) Dactinomycin 10 to 12 micrograms/kg IV push daily for five days | 77 to 94 |
2) Dactinomycin 1.25 mg/m2 IV push every two weeks | 69 to 90 |
Sequential chemotherapy | 100 |
Courtesy of Ross Berkowitz, MD; Donald Goldstein, MD; and Neil Horowitz, MD. Complete references are provided within the topic.
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