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Age at symptom onset by mutated gene in autosomal dominant Alzheimer disease

Age at symptom onset by mutated gene in autosomal dominant Alzheimer disease
Ages at symptom onset for all affected individuals are shown grouped by the affected gene, with APP mutations having an additional subclass for gene duplications.
APP: amyloid precursor protein; PS1: presenilin 1; PS2: presenilin 2.
From: Ryman D, Acosta-Baena N, Aisen P, et al. Symptom onset in autosomal dominant Alzheimer disease: A systematic review and meta-analysis. Neurology 2014; 83:253. DOI: 10.1212/WNL.0000000000000596. Reproduced with permission from Lippincott Williams & Wilkins. Copyright © 2014 American Academy of Neurology. Unauthorized reproduction of this material is prohibited.
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