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Relationship between body surface area (BSA) and drug clearance for six conventional chemotherapy agents

Relationship between body surface area (BSA) and drug clearance for six conventional chemotherapy agents
For irinotecan, apparent clearance corresponding to SN-38 was considered. R2 values indicate the contribution of BSA to the inter-individual variability in clearance.
Reprinted by permission from Macmillan Publishers Ltd on behalf of Cancer Research UK: British Journal of Cancer. Chatelut E, White-Koning ML, Mathijssen RH, et al. Dose banding as an alternative to body surface area-based dosing of chemotherapeutic agents. Br J Cancer 2012; 107:1100. Copyright © 2012. www.nature.com/bjc.
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