Relationship between body surface area (BSA) and drug clearance for six conventional chemotherapy agents
For irinotecan, apparent clearance corresponding to SN-38 was considered. R2 values indicate the contribution of BSA to the inter-individual variability in clearance.
Reprinted by permission from Macmillan Publishers Ltd on behalf of Cancer Research UK: British Journal of Cancer. Chatelut E, White-Koning ML, Mathijssen RH, et al. Dose banding as an alternative to body surface area-based dosing of chemotherapeutic agents. Br J Cancer 2012; 107:1100. Copyright © 2012.
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