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Differential diagnosis of vesicles and bullae on the vulva

Differential diagnosis of vesicles and bullae on the vulva
Common Less common Rare
  • Herpes simplex virus
  • Herpes zoster
  • Bullous impetigo
  • Erythema multiforme
  • Contact dermatitis
  • Autoimmune blistering diseases
    • Bullous pemphigoid
    • Pemphigoid gestationis (herpes gestationis)
    • Pemphigus vulgaris
    • Cicatricial pemphigoid (mucous membrane pemphigoid)
  • Fixed drug eruption
  • Hailey-Hailey disease
  • Lymphangioma/lymphangiectasia 
  • Bullous lichen sclerosus 
  • Other autoimmune conditions
    • Stevens-Johnson syndrome 
    • Toxic epidermal necrolysis 
    • Linear IgA bullous dermatosis
    • Epidermolysis bullosa acquisita
The prevalence categories refer to vulvar manifestations of the listed diseases. The relative frequency of each may vary based on the patient population, geography, and type of clinical practice (eg, gynecology, dermatology, or internal medicine).
IgA: immunoglobulin A.
Graphic 95995 Version 7.0