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Differential diagnosis of brown, blue, or black macules, papules, patches, and plaques on the vulva

Differential diagnosis of brown, blue, or black macules, papules, patches, and plaques on the vulva
Common Less common Rare
  • Physiologic hyperpigmentation
  • Postinflammatory hyperpigmentation
  • Low-grade squamous intraepithelial lesions
  • High-grade squamous intraepithelial lesions
  • Melanocytic nevus
  • Seborrheic keratosis
  • Angiokeratoma
  • Skin tags (acrochordons)
  • Lentiginosis/vulvar melanosis 
  • Lichen planus
  • Atypical melanocytic nevus
  • Melanoma 
  • Varicosity  
  • Pigmented basal cell cancer
  • Hidradenoma papilliferum
  • Acanthosis nigricans
The prevalence categories refer to vulvar manifestations of the listed diseases. The relative frequency of each may vary based on the patient population, geography, and type of clinical practice (eg, gynecology, dermatology, or internal medicine).
Graphic 95978 Version 6.0

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