Antigen | ANA staining pattern | Approximate frequency in all patients (%) | Clinical associations | Organ involvement |
Scl-70 (topoisomerase-1) | Speckled | 10 to 40 | dcSSc | Lung fibrosis, isolated pulmonary hypertension less likely |
Centromere | Centromere (kinetochore) | 15 to 40 | lcSSc | Pulmonary hypertension, esophageal disease, "protection" from lung fibrosis and renal disease |
RNA polymerase III | Fine speckled nucleolar | 4 to 25 | dcSSc | Renal, skin, malignancy |
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