Primary biliary cholangitis (primary biliary cirrhosis), stage IV
Primary biliary cholangitis (primary biliary cirrhosis), stage IV
Trichrome stain highlighting the irregular nodules, commonly referred to as the "jigsaw puzzle" appearance of primary biliary cholangitis. The hepatocytes are surrounded by broad, acellular fibrous bands. The hepatocytes close to the fibrous bands appear lighter in color, giving off a halo effect. This is due to cholate stasis.