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Acquired disorders/conditions associated with increased fetal hemoglobin (Hb F)

Acquired disorders/conditions associated with increased fetal hemoglobin (Hb F)
Delayed switch from fetal to adult hemoglobin (Hb F to Hb A)
Prematurity
Infants of diabetic mothers
Trisomy 13
Bone marrow regeneration/increased erythropoiesis
After acute blood loss
After iron replacement in severe iron deficiency
Following chemotherapy
Following hematopoietic stem cell transplant
Acute hemolysis
During recovery from transient erythroblastopenia of childhood (TEC)
Pregnancy-associated erythroid expansion
Inherited and acquired bone marrow failure
Fanconi anemia, dyskeratosis congenita, Diamond-Blackfan anemia, Shwachman-Diamond syndrome
Acquired aplastic anemia
Malignancies
Juvenile myelomonocytic leukemia (JMML)
Other hematologic malignancies (AML, MDS, erythroleukemia, ALL, CML)
Solid tumors (choriocarcinoma, adenocarcinoma of the lung, hepatoma)
With the exception of trisomy 13, Hb F increases in the categories of delayed hemoglobin switching and bone marrow regeneration are likely to be transient. Refer to UpToDate for additional discussion of the causes and mechanisms of increased Hb F.
AML: acute myeloid leukemia; MDS: myelodysplastic syndrome; ALL: acute lymphocytic leukemia; CML: chronic myelogenous leukemia.
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