Adverse event | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 |
Hypercalcemia | Corrected serum calcium >ULN to 11.5 mg/dL; >ULN to 2.9 mmol/L; ionized calcium >ULN to 1.5 mmol/L | Corrected serum calcium >11.5 to 12.5 mg/dL; >2.9 to 3.1 mmol/L; ionized calcium >1.5 to 1.6 mmol/L; symptomatic | Corrected serum calcium >12.5 to 13.5 mg/dL; >3.1 to 3.4 mmol/L; ionized calcium >1.6 to 1.8 mmol/L; hospitalization indicated | Corrected serum calcium >13.5 mg/dL; >3.4 mmol/L; ionized calcium >1.8 mmol/L; life-threatening consequences | Death |
Hyperkalemia | >ULN to 5.5 mmol/L (mEq/L) | >5.5 to 6.0 mmol/L (mEq/L) | >6.0 to 7.0 mmol/L (mEq/L); hospitalization indicated | >7.0 mmol/L (mEq/L); life-threatening consequences | Death |
Hypermagnesemia | >ULN to 3.0 mg/dL; >ULN to 1.23 mmol/L | >3.0 to 8.0 mg/dL; >1.23 to 3.30 mmol/L | >8.0 mg/dL; >3.30 mmol/L; life-threatening consequences | Death | |
Hypernatremia | >ULN to 150 mmol/L (mEq/L) | >150 to 155 mmol/L (mEq/L) | >155 to 160 mmol/L (mEq/L); hospitalization indicated | >160 mmol/L (mEq/L); life-threatening consequences | Death |
Hyperphosphatemia | Laboratory finding only and intervention not indicated | Noninvasive intervention indicated | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated | Life-threatening consequences; urgent intervention indicated (eg, dialysis) | Death |
Hyperuricemia | >ULN without physiologic consequences | >ULN with physiologic consequences | Life-threatening consequences | Death | |
Hypocalcemia | Corrected serum calcium <LLN to 8.0 mg/dL; <LLN to 2.0 mmol/L; ionized calcium <LLN to 1.0 mmol/L | Corrected serum calcium <8.0 to 7.0 mg/dL; <2.0 to 1.75 mmol/L; ionized calcium <1.0 to 0.9 mmol/L; symptomatic | Corrected serum calcium <7.0 to 6.0 mg/dL; <1.75 to 1.5 mmol/L; ionized calcium <0.9 to 0.8 mmol/L; hospitalization indicated | Corrected serum calcium <6.0 mg/dL; <1.5 mmol/L; ionized calcium <0.8 mmol/L; life-threatening consequences | Death |
Hypokalemia | <LLN to 3.0 mmol/L (mEq/L) | <LLN to 3.0 mmol/L (mEq/L); symptomatic; intervention indicated | <3.0 to 2.5 mmol/L (mEq/L); hospitalization indicated | <2.5 mmol/L (mEq/L); life-threatening consequences | Death |
Hypomagnesemia | <LLN to 1.2 mg/dL; <LLN to 0.5 mmol/L | <1.2 to 0.9 mg/dL; <0.5 to 0.4 mmol/L | <0.9 to 0.7 mg/dL; <0.4 to 0.3 mmol/L | <0.7 mg/dL; <0.3 mmol/L; life-threatening consequences | Death |
Hyponatremia | <LLN to 130 mmol/L (mEq/L) | 125 to 129 mmol/L (mEq/L) and asymptomatic | 125 to 129 mmol/L (mEq/L) symptomatic; 120 to 124 mmol/L regardless of symptoms | <120 mmol/L (mEq/L); life-threatening consequences | Death |
Hypophosphatemia | Laboratory finding only and intervention not indicated | Oral replacement therapy indicated | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated | Life-threatening consequences | Death |
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