Class | Agent | Dose |
Penicillin-beta-lactamase combinations* | Piperacillin-tazobactam | 4.5 g IV every 6 hours |
Ticarcillin-clavulanate (not available in the United States or Canada) | 3.1 g IV every 4 hours | |
Cephalosporins | Ceftazidime | 2 g IV every 8 hours |
Cefepime | 2 g IV every 8 or 12 hours¶ | |
Cefoperazone | 2 g IV every 12 hours | |
CefiderocolΔ | 2 g IV every 8 hours | |
Monobactams | Aztreonam | 2 g IV every 8 hours |
Fluoroquinolones◊ | Ciprofloxacin | 400 mg IV every 8 to 12 hours or 750 mg orally every 12 hours |
Levofloxacin | 750 mg IV or orally once daily | |
Carbapenems§ | Meropenem | 1 g IV every 8 hours |
Doripenem | 500 mg IV every 8 hours | |
Imipenem | 500 mg IV every 6 hours¥ | |
Advanced beta-lactamase inhibitor combinationsΔ | Ceftazidime-avibactam | 2.5 g IV every 8 hours |
Ceftolozane-tazobactam | 1.5 to 3 g IV every 8 hours‡ | |
Imipenem-cilastatin-relebactam | 1.25 g IV every 6 hours | |
Aminoglycosides† | Tobramycin | Dosing of aminoglycosides is discussed in detail in a dedicated topic |
Gentamicin | ||
Amikacin | ||
Plazomicin | ||
Polymyxins** | Colistin | Dosing of polymyxins is discussed in detail in a dedicated topic |
Polymyxin B |
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