Version October 2024
| Pharmacologic class | Usual adult dosing | Pediatric dosing |
| Antihistamines with mast cell-stabilizing properties: Decreased itching should be evident within 24 to 72 hours; may result in dry eye sensation or burning | ||
| Olopatadine 0.1% and 0.2% (OTC Pataday, generics), 0.7% (OTC Pataday) | One drop per eye twice daily (0.1%); one drop per eye once daily (0.2% and 0.7%) | ≥2 years: One drop per eye twice daily (0.1%); one drop per eye once daily (0.2% and 0.7%) |
| Alcaftadine 0.25% (OTC Lastacaft) | One drop per eye once daily | ≥2 years: One drop per eye once daily |
| Bepotastine 1.5% (Bepreve, generics) | One drop per eye twice daily | ≥2 years: One drop per eye twice daily |
| Cetirizine 0.24% (Zerviate) | One drop per eye twice daily | ≥2 years: One drop per eye twice daily |
| Epinastine 0.05% (generics) | One drop per eye twice daily | ≥2 years: One drop per eye twice daily |
| Ketotifen fumarate 0.035% (ketotifen 0.025%; multiple OTC products) | One drop per eye twice daily | ≥3 years: One drop per eye twice daily |
| Azelastine 0.05% (generics) | One drop per eye twice daily | ≥3 years: One drop per eye twice daily |
| Emedastine 0.05% (not available in US but may be available in other countries) | One drop per eye up to 4 times daily | ≥3 years: One drop per eye up to 4 times daily |
| Vasoconstrictor/antihistamine combination: Increased redness can occur temporarily when medication is stopped | ||
| Naphazoline 0.25% and pheniramine 0.3% (OTC Naphcon-A, OTC Visine, OTC Visine-A) Naphazoline 0.27% and pheniramine 0.315% (OTC Opcon-A, generics) | One to two drops per eye up to 4 times daily | ≥6 years: One to two drops per eye up to 4 times daily |
| Mast cell stabilizers: Decreased itching may be evident within a few days or may take up to four weeks | ||
| Cromolyn sodium 4% (generics) | One to two drops per eye up to 6 times daily | ≥4 years: One to two drops per eye up to 6 times daily |
| Nedocromil 2% (Alocril) | One to two drops per eye twice daily | ≥3 years: One to two drops per eye twice daily |
| Lodoxamide 0.1% (Alomide) | One to two drops per eye 4 times daily for up to 3 months | >2 years: One to two drops per eye 4 times daily for up to 3 months |
| Pemirolast 0.1% (not available in US but may be available in other countries) | One to two drops per eye up to 4 times daily for up to 4 weeks | ≥3 years: One to two drops per eye up to 4 times daily for up to 4 weeks |
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