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Risk factors for rickets in preterm infants

Risk factors for rickets in preterm infants
Prematurity and very low birth weight (<1500 g)
Fetal growth restriction, especially infants with birth weight <3rd percentile for gestational age (refer to UpToDate content on fetal [intrauterine] growth restriction)
Long-term parenteral nutrition (>4 weeks)
Bronchopulmonary dysplasia treated with loop diuretics and/or fluid restriction
Long-term postnatal corticosteroid use
History of necrotizing enterocolitis or other diseases causing intestinal failure, especially in patients who undergo surgical intervention
Feeds that do not have high mineral content (eg, due to poor tolerance of fortified feeds)
Metabolic or endocrine disorders including severe cholestasis or kidney disease
Adapted from: Abrams SA. Calcium and vitamin d requirements of enterally fed preterm infants. Pediatrics 2013; 131:e1676.
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