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Definitions of "high risk" stage II colon cancer from expert groups

Definitions of "high risk" stage II colon cancer from expert groups
  ASCO (2022) NCCN (2022) ESMO (2020)
T4 primary tumor + + + (major)
Inadequately sampled nodes +
(<12)
+
(<12)
+ (major)
(<12)
Poorly differentiated or undifferentiated tumor* + + + (minor)
Perforation + +
(localized)
+ (major)
Clinical obstruction + + + (minor)
LVI + + + (minor)
PNI + + + (minor)
Close/indeterminate or positive margins   +  
High preoperative levels of serum CEA     + (minor)
High tumor budding score (BD3, ≥10 buds) +    
ASCO: American Society of Clinical Oncology; NCCN: National Comprehensive Cancer Network; ESMO: European Society for Medical Oncology; LVI: lymphovascular invasion; PNI: perineural invasion; CEA: carcinoembryonic antigen.
* Poorly differentiated or undifferentiated histology (only a high risk feature for tumors with proficient mismatch repair/no microsatellite instability).
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