ASCO (2022) | NCCN (2022) | ESMO (2020) | |
T4 primary tumor | + | + | + (major) |
Inadequately sampled nodes | + (<12) | + (<12) | + (major) (<12) |
Poorly differentiated or undifferentiated tumor* | + | + | + (minor) |
Perforation | + | + (localized) | + (major) |
Clinical obstruction | + | + | + (minor) |
LVI | + | + | + (minor) |
PNI | + | + | + (minor) |
Close/indeterminate or positive margins | + | ||
High preoperative levels of serum CEA | + (minor) | ||
High tumor budding score (BD3, ≥10 buds) | + |
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