Graph showing reduction in creatinine clearance after NSAIDs in patients with hepatic cirrhosis

Reduction in glomerular filtration rate, as estimated from the creatinine clearance, from a mean of 73 mL/min down to 32 mL/min, after the administration of an NSAID (indomethacin or ibuprofen) to 12 patients with stable hepatic cirrhosis and ascites. Urinary prostaglandin E₂ excretion was initially elevated and then fell markedly following therapy.