Nature of operation | Common pathogens | Recommended antimicrobials | Usual adult dose | Redose interval |
Reduction mammoplasty Mammoplasty Lumpectomy Prophylactic mastectomy | – | None | – | – |
Breast cancer procedures (eg, axillary node dissection, mastectomy for known breast cancer) | Staphylococcus aureus, Staphylococcus epidermidis, streptococci* | Cefazolin | <120 kg: 2 g IV ≥120 kg: 3 g IV | 4 hours |
OR vancomycin | 15 mg/kg (max 2 g) | N/A | ||
OR clindamycin | 900 mg IV | 6 hours |
IV: intravenous.
* A higher rate of infection due to gram-negative organisms occurs in the setting of procedures involving macerated, moist environments (such as under the axilla of an individual with obesity) and among patients with diabetes. In the setting of risk for surgical site infections due to gram-negative pathogens, an additional agent may be warranted (such as gentamicin 5 mg/kg IV, aztreonam 2 g IV, ciprofloxacin 400 mg IV, or levofloxacin 500 mg IV).Do you want to add Medilib to your home screen?