Note: Not all available products may be represented in dosing; also refer to manufacturer’s labeling.
Mucositis (due to high-dose chemotherapy or radiation therapy): Oral:
Caphosol (dispersible tablet and solution), NeutraSal: Swish and spit 4 to 10 doses daily (use for the duration of chemo- or radiation therapy).
SalivaMax: Swish and spit 2 to 10 doses daily.
Xerostomia: Oral: Use as needed, or product-specific dosing:
Aquoral: Two sprays 3 to 4 times daily.
Biotene Dry Mouth Gentle oral rinse: Swish and spit 15 mL up to 3 times daily.
Biotene Oral Balance gel: Apply one-half inch length onto tongue and spread evenly; repeat as often as needed.
Biotene spray, Entertainer's Secret: Spray as often as needed.
Caphosol (dispersible tablet and solution), NeutraSal, SalivaMax: Swish and spit 2 to 10 doses daily.
Mouth Kote spray: Spray 3 to 5 times, swish for 8 to 10 seconds, then spit or swallow; use as often as needed.
Numoisyn liquid: Use 2 mL as needed.
Numoisyn lozenges: Dissolve 1 lozenge slowly; maximum 16 lozenges/day.
Oasis mouthwash: Rinse mouth with ~30 mL twice daily or as needed; do not swallow.
Oasis spray: 1 to 2 sprays as needed; maximum 60 sprays/day.
SalivaSure: Dissolve 1 lozenge slowly as needed; for severe symptoms, 1 lozenge per hour is recommended.
Xylimelts: Use as needed during the day; use 1 melt on each side of the mouth while sleeping.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Refer to adult dosing.
Xerostomia: Oral: Children ≥12 years of age and Adolescents: Biotene Dry Mouth Gentle oral rinse: Refer to adult dosing.
There are no adverse reactions listed in the manufacturer’s labeling.
Hypersensitivity to saliva substitute or any component of the formulation; fructose intolerance (Numoisyn lozenges only)
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Gel, oral:
Biotene Oral Balance: Glycerin, water, sorbitol, xylitol, carbomer, hydroxyethylcellulose, sodium hydroxide (42 g) [alcohol-free, sugar-free]
Liquid, oral:
Biotene Dry Mouth Gentle: Water, glycerin, xylitol, sorbitol, propylene glycol, poloxamer 407, potassium sorbate, hydroxyethylcellulose, sodium phosphate, cetylpyridinium chloride, disodium phosphate (473 mL) [alcohol-free; mild mint flavor]
Numoisyn: Water, sorbitol, linseed extract, Chondrus crispus, methylparaben, sodium benzoate, potassium sorbate, dipotassium phosphate, propylparaben (300 mL)
Lozenge, oral:
Numoisyn: Sorbitol 0.3 g/lozenge, polyethylene glycol, malic acid, sodium citrate, calcium phosphate dibasic, hydrogenated cottonseed oil, citric acid, magnesium stearate, silicon dioxide (100s)
SalivaSure: Xylitol, citric acid, apple acid, sodium citrate dihydrate, sodium carboxymethylcellulose, dibasic calcium phosphate, silica colloidal, magnesium stearate, stearic acid (90s)
Powder, for reconstitution, oral:
BocaSal: Calcium chloride, sodium bicarbonate, sodium chloride, and sodium phosphates (30s)
NeutraSal: Calcium chloride, sodium bicarbonate, sodium chloride, and sodium phosphates (120s)
SalivaMAX: Calcium chloride, sodium bicarbonate, sodium chloride, and sodium phosphates (30s, 120s)
Solution, oral:
Caphosol: Dibasic sodium phosphate 0.032%, monobasic sodium phosphate 0.009%, calcium chloride 0.052%, sodium chloride 0.569%, purified water (30 mL) [packaged in two 15 mL ampuls when mixed together provide one 30 mL dose]
Entertainer's Secret: Sodium carboxymethylcellulose, aloe vera gel, glycerin (60 mL) [ethanol free; honey-apple flavor]
Solution, oral [mouthwash/gargle]:
Oasis: Water, glycerin, sorbitol, poloxamer 338, PEG-60, hydrogenated castor oil, copovidone, sodium benzoate, carboxymethylcellulose (473 mL) [ethanol free, sugar free; mild mint flavor]
Solution, oral [spray]:
Aquoral: Oxidized glycerol triesters and silicon dioxide (10 mL) [contains aspartame; citrus flavor]
Biotene Moisturizing Mouth Spray: Water, polyglycitol, propylene glycol, sunflower oil, xylitol, milk protein extract, potassium sorbate, acesulfame K, potassium thiocyanate, lysozyme, lactoferrin, lactoperoxidase (45 mL)
Moi-Stir: Water, sorbitol, sodium carboxymethylcellulose, methylparaben, propylparaben, potassium chloride, dibasic sodium phosphate, calcium chloride, magnesium chloride, sodium chloride (120 mL)
Mouth Kote: Water, xylitol, sorbitol, yerba santa, citric acid, ascorbic acid, sodium saccharin, sodium benzoate (5 mL, 60 mL, 240 mL) [ethanol free, sugar free; lemon-lime flavor]
Oasis: Glycerin, cetylpyridinium, copovidone (30 mL) [ethanol free, sugar free; contains sodium benzoate; delivers ~150 sprays, mild mint flavor]
Xerostomia Relief: Oxidized glycerol triesters and silicon dioxide (10 mL) [contains aspartame]
No
Biotene Dry Mouth Gentle oral rinse: Rinse for 30 seconds.
Biotene Oral Balance gel: Apply on tongue and spread evenly.
Biotene spray: Spray directly into mouth; spray is safe to swallow.
Caphosol dispersible tablet: After dissolving tablet, swish thoroughly with 1/2 of mixture (25 mL) for 1 minute and spit; repeat. Avoid eating or drinking for at least 15 minutes after use.
Caphosol solution: Swish mixed solution thoroughly with 1/2 of mixture (15 mL) for 1 minute and spit; repeat. Avoid eating or drinking for at least 15 minutes after use.
Entertainer's Secret: Tilt head back and spray into throat or nostril while inhaling sharply.
Mouth Kote spray: Spray into mouth and swirl for 8 to 10 seconds; spray may be swallowed or spit out.
NeutraSal, SalivaMax: For each dose, swish 1/2 the prepared solution around the mouth for at least 1 minute and spit out; repeat with the remaining solution. Avoid eating or drinking for at least 15 minutes (NeutraSal) or 30 minutes (SalivaMax) after use.
Numoisyn liquid: Rinse in mouth before swallowing.
Numoisyn lozenges: Dissolve slowly in mouth; move lozenge around mouth for optimal effect.
Oasis mouthwash: Rinse for 30 seconds.
Oasis spray: Spray into mouth holding bottle upright; do not rinse.
SalivaSure lozenges: Allow lozenge to move around and slowly dissolve in mouth.
XyliMelts: Place tan adhesive side on the outside of a molar and/or adjoining gums, upper or lower, white side touching cheek. Hold in place 10 seconds to secure.
Oral: Biotene Dry Mouth Gentle oral rinse: Rinse for 30 seconds, then spit; do not swallow. May cause staining.
Mucositis (due to high-dose chemotherapy or radiation therapy): Adjunct to standard oral care in relief of symptoms associated with chemotherapy or radiation therapy-induced mucositis
Xerostomia: Relief of dry mouth and throat in xerostomia or hyposalivation
None known.
There are no known significant interactions.
Caphosol: Dispersible tablet formulation contains sodium 1 g/50 mL dose and solution formulation contains sodium 71 mg/30 mL dose
Moi-Stir: Contains sodium: 6.47 mEq/120 mL, potassium: 1.93 mEq/120 mL, magnesium: 0.128 mEq/120 mL
Protein or electrolyte mixtures which restore/replace saliva, lubricate, moisten, clean, and/or provide a coating on oral mucosa
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