Polysaccharide vaccine | Conjugate polysaccharide vaccine | |
Stimulates antibodies in infants and toddlers | No | Yes |
Stimulates antibodies in healthy adults | Yes | Yes |
Stimulates antibodies in immunocompromised adults | +/- | +/- |
Antibodies are long-lasting | +/- | +/- |
Primes immunologically for enhanced responses | No | Possibly |
Stimulates mucosal immunity, resulting in decreased colonization | No | Yes |
Exhibits herd effect (secondary protection of unvaccinated individuals) | No | Yes |
Use is associated with replacement strains | No | Yes |
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