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Pathways involved in kinin-mediated angioedema and actions of C1 esterase inhibitor

Pathways involved in kinin-mediated angioedema and actions of C1 esterase inhibitor

C1INH: C1 esterase inhibitor; C4: complement component 4.

* In the disorder hereditary angioedema (HAE) with factor XII variants, factor XII may be prone to excessive activation.

Data from:
  1. Morgan PB. Hereditary angioedema – therapies old and new. N Engl J Med 2010; 363:581.
  2. Longhurst H, Cicardi M. Hereditary angio-oedema. Lancet 2012; 379:474.
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