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Pathways involved in kinin-mediated angioedema and actions of drugs

Pathways involved in kinin-mediated angioedema and actions of drugs
C4: complement component 4; C1INH: C1 inhibitor.
* In the disorder hereditary angioedema (HAE) with factor XII mutations, factor XII may be prone to excessive activation.
Data from:
  1. Morgan PB. Hereditary angioedema—therapies old and new. N Engl J Med 2010; 363:581.
  2. Longhurst H, Cicardi M. Hereditary angio-oedema. Lancet 2012; 379:474.
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