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Version October 2024
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Endoscopic and histological staging of upper gastrointestinal graft-versus-host disease (GI-GVHD)
Endoscopic and histological staging of upper gastrointestinal graft-versus-host disease (GI-GVHD)
Upper panel: Endoscopic views of duodenum with the four grades of GI-GVHD. Grade 1 = loss of vascular markings and/or focal mild erythema; grade 2 = moderate edema and/or erythema; grade 3 = edema, erythema, erosions, and/or bleeding; grade 4 = ulceration, exudates, and bleeding.
Lower panel: Photomicrographs of the duodenum corresponding to the above endoscopic images. Grade 1 = increased crypt apoptosis (arrow); grade 2 = apoptosis with crypt abscess (arrow); grade 3 = individual crypt necrosis (arrows); grade 4 = total denudation of areas of mucosa (hematoxylin and eosin [H & E]; x220).
Reproduced with permission from: Cruz-Correa M, Poonawala A, Abraham SC, et al. Endoscopic findings predict the histologic diagnosis in gastrointestinal graft-versus-host disease. Endoscopy 2002; 34:808. Copyright © 2002 Thieme Publishers.
Graphic 86936 Version 1.0
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