Syndrome | Rash morphology | Localization | Timing | Internal organ involvement | Systemic signs | Laboratory findings |
DRESS | Maculopapular exanthem Erythroderma Facial edema Purpura, pustules | Generalized Mucosal involvement infrequent | 2 to 6 weeks | Lymphadenopathy Hepatitis Pneumonitis Nephritis Thyroiditis Myocarditis Eosinophilia | Fever (>38°C/100.4°F) Malaise Fatigue | Eosinophilia, atypical lymphocytes Abnormal liver, renal function tests |
AGEP | Intertriginous erythema, maculopapular exanthem, widespread nonfollicular pinpoint pustules | Generalized, rarely flexural Mucosal involvement rare | 1 to 11 days | Liver, renal, pulmonary may be involved but generally mild | Fever (>38°C/100.4°F) | Leukocytosis with neutrophilia (>7000/mm3) |
SJS/TEN | Dusky red confluent erythema, atypical target lesions, purpura, blisters, and sheet-like detachment Nikolsky sign is positive SJS <10%, SJS/TEN 10 to 30%, TEN >30% | Disseminated Mucosal involvement nearly in all cases | 4 to 28 days | Pneumonitis, hepatitis, acute renal failure, GI, leucopenia | Fever (>38°C/100.4°F) Malaise Fatigue Sore throat Dysphagia, photophobia | Lymphopenia Epidermal necrosis on skin biopsy with full thickness loss of epidermis |
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