Clinical manifestation | Chronology | Morphology and localization |
Urticaria | - Immediate
- Minutes to 2 hours
- Rapid change and resolution of single lesions (<24 hours)
| - Urticarial wheals, pale swelling surrounded by erythematous border
- Pruritus
- Trunk, face, mucosae, or generalized
|
Angioedema | - Immediate to delayed
- Minutes up to 6 hours
- Resolution 24 to 72 hours
| - Pale swelling
- Dysesthesia, pain
- Face, lips, eye lids, mucosa, male genitals
|
Maculopapular exanthem | - Delayed
- Typically 6 to 24 hours
- Peak at 48 to 72 hours
- Resolution 1 week
| - Macules, papules
- Confluence, desquamation
- Trunk, proximal extremities, or disseminated
|
Fixed drug eruption | - Delayed
- Typically 30 minutes to 8 hours
- Resolution 7 to 10 days
| - Erythematous or lilac macule or plaque, central bulla/erosion, permanent hyperpigmentation, burning, pruritus
- Fixed (identical site)
- Acral or mucosal localization
|
Pustular exanthem (AGEP) | - Delayed
- Typically 6 to 12 hours up to 48 hours
- Resolution 1 week
| - Confluent erythema; pinpoint, nonfollicular pustules; pruritus; massive desquamation
- Folds, trunk, or generalized
|
Vesicobullous exanthems | - Delayed
- Typically 24 to 48 hours
- Resolution several weeks
| - Macules, bullae, epidermolysis, mucositis
- Initially painful skin
- Trunk, face, or generalized
|