Classical* |
1. Abrupt onset of painful erythematous plaques or nodules |
2. Histopathologic evidence of a dense neutrophilic infiltrate without evidence of leukocytoclastic vasculitis |
3. Pyrexia >38°C |
4. Association with an underlying hematologic or visceral malignancy, inflammatory disease, or pregnancy, or preceded by an upper respiratory or gastrointestinal infection or vaccination |
5. Excellent response to treatment with systemic corticosteroids or potassium iodide |
6. Abnormal laboratory values at presentation (three of four): erythrocyte sedimentation rate >20 mm/hr; positive C-reactive protein; >8,000 leukocytes; >70 percent neutrophils |
Drug-induced¶ |
A. Abrupt onset of painful erythematous plaques or nodules |
B. Histopathologic evidence of a dense neutrophilic infiltrate without evidence of leukocytoclastic vasculitis |
C. Pyrexia >38°C |
D. Temporal relationship between drug ingestion and clinical presentation, or temporally-related recurrence after oral challenge |
E. Temporally-related resolution of lesions after drug withdrawal or treatment with systemic corticosteroids |
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