Examples of the two major patterns of tumor evolution in acute myeloid leukemia
Examples of the two major patterns of tumor evolution in acute myeloid leukemia
Model 1 shows the dominant clone in the primary tumor evolving into the relapse clone by gaining relapse specific mutations; this pattern was identified in three primary tumor and relapse pairs. Model 2 shows a minor clone carrying the vast majority of the primary tumor mutations survived and expanded at relapse. This pattern was observed in five primary tumor and relapse pairs.