Risk factor | Breast cancer risk ratio (95% CI) | Source (reference) |
≥2-fold increased risk | ||
First-degree relatives with breast cancer | ||
1 | 2.14 (1.92-2.38) | 1 |
2 | 3.84 (2.37-6.22) | 1 |
Age of first-degree relative with breast cancer | ||
<40 years | 3.0 (1.8-4.9) | 1 |
<50 years | 2.17 (1.86-2.53) | BCSC |
Breast density BI-RADS category 4 | 2.04 (1.84-2.26) | 2* |
1.5- to 2.0-fold increased risk | ||
Prior benign breast biopsy result | 1.87 (1.64-2.13) | 3* |
Second-degree relative with breast cancer | 1.7 (1.4-2.0) | 4 |
Breast density BI-RADS category 3 | 1.62 (1.51-1.75) | 2* |
1.0- to 1.5-fold increased risk | ||
Current oral contraceptive use | 1.30 (1.13-1.49) | BCSC |
Nulliparity¶ | 1.25 (1.08-1.46) | 5-9 |
Age at first birth ≥30 yearsΔ | 1.20 (1.02-1.42) | 5-9 |
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