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Features identified by the National Comprehensive Cancer Network as risk factors for recurrence of cutaneous squamous cell carcinoma

Features identified by the National Comprehensive Cancer Network as risk factors for recurrence of cutaneous squamous cell carcinoma
Location/size*
Poorly defined borders
Recurrent tumors
Immunosuppressed patient
Site of previous radiation therapy or chronic inflammation
Rapidly growing tumor
Neurologic symptoms
Poorly differentiated tumor
Acantholytic (adenoid), adenosquamous, desmoplastic, or metaplastic (carcinosarcomatous) subtypes
Depth ≥2 mm or Clark level IV or V
Perineural, lymphatic, or vascular involvement
* Size ≥20 mm on trunk or extremities (excluding pretibia, hands, feet, nail units, and ankles); size ≥10 mm on cheeks, forehead, scalp, neck, or pretibia; size ≥6 mm on "mask areas" of the face (central face, eyelids, eyebrows, periorbital nose, lips [cutaneous and vermilion], chin, mandible, preauricular and postauricular skin/sulci, temple, ear, genitalia, hands, and feet).
Adapted from: NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®): Squamous Cell Skin Cancer, Version 2.2018.
Graphic 83683 Version 5.0

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