Location/size* |
Poorly defined borders |
Recurrent tumors |
Immunosuppressed patient |
Site of previous radiation therapy or chronic inflammation |
Rapidly growing tumor |
Neurologic symptoms |
Poorly differentiated tumor |
Acantholytic (adenoid), adenosquamous, desmoplastic, or metaplastic (carcinosarcomatous) subtypes |
Depth ≥2 mm or Clark level IV or V |
Perineural, lymphatic, or vascular involvement |
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