Short-term prophylaxis to prevent angioedema in hereditary angioedema (HAE)

High-risk procedures	Lower-risk procedures
Intubation, oral surgery (cutting of tissues), dental procedures involving injections of anesthetics, general surgery, other procedures that precipitated past attacks in that patient.	Routine dental cleanings.
Option 1: Give plasma-derived C1 inhibitor concentrate one hour before procedure, with two additional doses available on demand*.	No additional treatment in advance but have treatment for acute angioedema immediately available if symptoms develop (ie, C1 inhibitor concentrate, ecallantide, or icatibant).
Option 2: If option 1 is not possible, then give premedication with androgens for five days before and three days after. Example: Danazol, 10 mg/kg per day up to 600 mg daily or equivalent doses of another attenuated androgen

* Ecallantide and icatibant have not been studied for use in prophylaxis, although they can be given if angioedema develops.

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