Reference | Number of patients | Radiotherapy | Antiemetic | Complete response (percent) | Results |
Priestman1 | 82 | 8-10 Gy single fraction | OND (8 mg x 3/day PO for 5 days) | 97 | OND better than MCP |
MCP (10 mg x 3/day PO for 5 days) | 46 | ||||
Priestman2 | 135 | 1.8 Gy/day for at least 5 fractions | OND (8 mg x 3/day PO) | 61 | OND better than MCP for vomiting |
MCP (10 mg x 3/day PO) | 35 | ||||
Bey3 | 50 | At least 6 Gy single fraction | DOL (0.3 mg/kg IV) | 100* | DOL better than placebo |
DOL (0.6 mg/kg IV) | 93* | ||||
DOL (1.2 mg/kg IV) | 83* | ||||
Placebo | 54* | ||||
Franzen4 | 111 | At least 1.7 Gy/day for ≥10 fractions | OND (8 mg x 2/day PO) | 67 | OND better than placebo |
Placebo | 45 | ||||
Aass5 | 23 | 2 Gy/day to 30 Gy in 15 fractions | TRO (5 mg/day PO) | 91 | TRO better than MCP |
MCP (10 mg x 3/day PO) | 50 | ||||
Lanciano6 | 260 | 10-30 fractions | GRAN (2 mg/day) | 57.5 | GRAN better than placebo |
(1.8-3 Gy/fraction) | Placebo | 42 | |||
Kirkbride7 | 154 | At least 5 fractions to minimum total dose of 20 Gy | DEX (2 mg x 3/day PO for 5-7 days) | 70 | DEX better than placebo |
Placebo | 49 | ||||
Wong8 | 211 | ≥15 fractions to the upper abdomen to a dose of 20 or more Gy | OND (8 mg BID for 5 days) + placebo for 5 days | 71¶ 12Δ | OND + DEX better than OND alone |
OND (8 mg BID) + DEX (4 mg for 5 days) | 78¶ 23Δ | ||||
Mystakidou9 | 288 | Fractionated radiotherapy of moderate or high emetogenic potential | TRO 5 mg daily starting 1 day before radiotherapy until 7 days after end of radiotherapy | Incidence of vomiting was 2.19 times higher in rescue arm | Prophylactic TRO better than rescue TRO |
TRO 5 mg on an as needed basis |
Do you want to add Medilib to your home screen?