G6PD risk* | Description | |
Systemic agents¶ | ||
Sulfadiazine | Low | As single agent or in combination with pyrimethamine |
Sulfadoxine | As single agent or in combination with pyrimethamine; long-acting◊ | |
SulfaguanidineΔ | Low | Gastrointestinal antimicrobial |
SulfamerazineΔ | Low | In combination with other sulfonamides or trimethoprim |
SulfamethizoleΔ | Urinary tract antimicrobial | |
Sulfamethazine (sulfadimidine)Δ | High | As single agent or in combination with other sulfonamides |
Sulfamethoxazole | Variable | In combination with trimethoprim or as single agent |
SulfametopyrazineΔ | In combination with pyrimethamine; long-acting◊ | |
SulfamoxoleΔ | In combination with trimethoprim | |
SulfapyridineΔ | Rarely used due to crystalluria risk | |
Sulfasalazine (salazosulfapyridine, salazopyrin) | High | Rheumatologic/gastrointestinal agent (nonantimicrobial); releases sulfapyridine in contact with gut flora |
Sulfisoxazole (sulfafurazole) | High | As single agent or in combination with erythromycin |
Topical and ophthalmic agents | ||
Mafenide | Topical solution or cream | |
Silver sulfadiazine | Low | Topical cream or ointment |
Sulfacetamide | High | As single agent ophthalmic solution, ointment, various topicals, vaginal or in combination with sulfabenzamide, sulfathiazole, or prednisolone |
Sulfanilamide | High | As single agent vaginal or in combination with other antimicrobials |
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