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Classification of GCTs according to tumor markers

Classification of GCTs according to tumor markers
Tumor type Marker
β-HCG AFP PLAP c-Kit
Pure germinoma - - +/- +
Germinoma (syncytiotrophoblastic) + - +/- +
Endodermal sinus tumor - + +/- -
Choriocarcinoma + - +/- -
Embryonal carcinoma - - + -
Mixed GCT +/- +/- +/- +/-
Mature teratoma - - - -
Immature teratoma +/- +/- - +/-
WHO_GCTs.htm
AFP: alpha-fetoprotein; β-HCG: β-human chorionic gonadotropin; GCT: germ cell tumor; PLAP: placental alkaline phosphatase.
Reproduced with permission from: Louis DN, Ohgaki H, Wiesterl O, et al. World Health Organization Classification of Tumours of the Central Nervous System, 3rd Edition, IARC Press, Lyon, 2007. Copyright © 2007 IARC Press.
Graphic 81974 Version 9.0

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