Systemic allergic reactions |
Anaphylaxis |
Serum sickness |
Cutaneous reactions |
Rash |
Stevens-Johnson syndrome |
Erythema muliforme |
Urticaria |
Toxic epidermal necrolysis |
Photodermatis |
Gastrointestinal and hepatic reactions |
Nausea and vomiting |
Diarrhea |
Hepatotoxicity |
Hematologic reactions |
Pancytopenia |
Agranulocytosis |
Anemia |
Thrombocytopenia |
Renal disorders |
Transient rise in creatinine due to impaired secretion by trimethoprim |
Acute interstitial nephritis |
Crystalluria due to precipitation of sulfamethoxazole |
Hyperkalemia due to trimethoprim-induced blockade of collecting tubule sodium channel |
Other reactions |
Central nervous system - headache, confusion, aseptic meningitis |
Fever |
Phlebitis |
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