Distribution of all primary brain and CNS tumors by major histopathology grouping

Histology	Percent of total	Annual incidence rate^*
Diffuse astrocytic and oligodendroglial tumors	18.6	4.45
Diffuse astrocytoma	1.6	0.44
Anaplastic astrocytoma	1.5	0.39
Glioblastoma	14.2	3.27
Oligodendroglioma	0.8	0.23
Anaplastic oligodendroglioma	0.4	0.11
Oligoastrocytic tumors	<0.1	0.01
Other astrocytic tumors	1.4	0.43
Pilocytic astrocytoma	1.2	0.37
Unique astrocytoma variants	0.2	0.43
Ependymal tumors	1.5	0.41
Other gliomas	2.0	0.55
Neuronal and mixed neuronal-glial tumors	1.2	0.34
Choroid plexus tumors	0.2	0.05
Tumors of the pineal region	0.2	0.05
Embryonal tumors	0.7	0.21
Tumors of cranial and spinal nerves	8.1	2.00
Nerve sheath tumors	8.1	2.00
Tumors of meninges	42.1	10.06
Meningioma	40.8	9.73
Mesenchymal tumors	1.3	0.33
Primary melanocytic lesions		0.01
Lymphomas and hematopoietic neoplasms	1.9	0.44
Lymphoma	1.9	0.44
Other hematopoietic neoplasms	<0.1	0.00
Germ cell tumors	0.3	0.08
Tumors of sellar region	17.9	4.72
Tumors of the pituitary	17.2	4.54
Craniopharyngioma	0.7	0.18
Unclassified tumors	4.1	1.02
Hemangioma	1.0	0.26
Neoplasm, unspecified	3.0	0.73
All other	0.1	0.03
TOTAL	453,623	100.0

CBTRUS Statistical Report: NPCR and SEER data from 2016 to 2020.

CBTRUS: Central Brain Tumor Registry of the United States; CNS: central nervous system; NOS: not otherwise specified; NPCR: National Program of Cancer Registries; SEER: Surveillance, Epidemiology, and End Results Program.

* Average annual age-adjusted incidence rate.

Data from: Ostrom QT, Price M, Neff C, et al. CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2016-2020. Neuro Oncol 2023; 25:iv1.

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Distribution of all primary brain and CNS tumors by major histopathology grouping