Facial features | Frontal bossing, saddle nose, short maxilla, protuberant mandible |
Ophthalmologic | Interstitial keratitis, chorioretinitis, secondary glaucoma, corneal scarring, optic atrophy |
Ears | Sensorineural hearing loss |
Oropharynx | Hutchinson teeth, mulberry molars, perforation of hard palate |
Cutaneous | Rhagades, gummas |
Central nervous system | Intellectual disability, arrested hydrocephalus, seizures, optic atrophy, juvenile general paresis |
Skeletal | Saber shins (anterior bowing of the tibia), Higoumenakis sign (enlargement of the sternoclavicular portion of the clavicle), Clutton joints (painless arthritis), scaphoid scapula |
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