Inherited enzyme defects leading to purine overproduction (rare monogenic disorders) |
Hypoxanthine-guanine phosphoribosyltransferase deficiency |
Phosphoribosylpyrophosphate synthetase overactivity |
Glucose-6-phosphatase deficiency (glycogen storage disease, type I) |
Clinical disorders leading to purine and/or urate overproduction |
Myeloproliferative disorders |
Lymphoproliferative disorders |
Hemolytic disorders |
Psoriasis |
Tissue hypoxia |
Down syndrome |
Glycogen storage diseases (types III, V, VII) |
Drug- and diet-induced purine and/or urate overproduction |
Excessive ethanol ingestion |
Excessive dietary purine ingestion |
Excessive fructose ingestion |
Cytotoxic drugs |
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