Outcome of patients with Brugada syndrome depends upon the clinical presentation

In a study of 334 patients with the Brugada syndrome, the incidence of arrhythmic events (sudden cardiac death or documented ventricular fibrillation) during follow-up depended upon the clinical presentation. The outcome was best for those who were asymptomatic and presented with an abnormal ECG, intermediate for those presenting with syncope, and worst in patients with aborted sudden cardiac death.