Complete blood count |
Total lymphocyte number may be normal or low |
Other cell types normal |
Total hemolytic complement (CH50) normal |
Antibodies |
IgM low or absent |
IgG and IgA normal |
IgE may be normal or mildly elevated (elevations may indicate presence of associated allergic diseases) |
Flow cytometry of lymphocytes |
CD4+ T cells may be low or normal |
CD8+ T cells may be low or normal |
B cells and NK cells normal |
HIV testing negative |
Response to vaccination |
Response to pneumococcal polysaccharide vaccine (T cell-independent carbohydrate antigens) may be normal or impaired |
Response to diphtheria/tetanus vaccine (T cell-dependent protein antigens) may be normal or impaired |
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