Occupational asthma with a latency period | Irritant-induced asthma | |
Latency period | Present | Absent |
Diagnosis | Various – eg, peak expiratory flow monitoring, specific inhalation challenges; IgE-mediated allergy if suspected agent is of a high-molecular-weight nature | History; pulmonary function testing |
Pathology | Similar to asthma | Acute: epithelial shedding and hemorrhage |
Chronic: regeneration of epithelial cells; few lymphocytes and neutrophils; increased collagen deposition and thickness of basement membrane | ||
Pulmonary function testing | Better reversibility to bronchodilator | Less reversibility to bronchodilator |
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