Bone disease |
Decreased bone density, especially in postmenopausal females |
Increased fracture risk |
Biochemical markers of increased bone resorption |
Increased urinary pyridinoline and deoxypyridinoline excretion |
Increased urinary hydroxyproline excretion |
Heart disease |
Increased incidence of atrial fibrillation |
Increased heart rate and incidence of atrial premature beats |
Increased cardiac contractility |
Increased left ventricular mass index and septal and posterior wall thickness |
Laboratory abnormalities |
Decrease in serum total and LDL cholesterol concentrations |
Increased serum concentrations of hepatic enzymes and creatine kinase |
Increased serum concentration of SHBG |
Other |
Decreased time asleep at night |
Improved mood |
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