Pathogen | Preferred antimicrobial agents and dosing (adult) | Alternative antimicrobial agents and dosing (adult) |
Staphylococci | ||
Methicillin susceptible | Nafcillin 2 g IV every 4 hours Oxacillin 2 g IV every 4 hours Cefazolin 2 g IV every 8 hours Flucloxacillin* 2 g IV every 6 hours | Vancomycin (dosing as summarized below) |
Methicillin resistant | Vancomycin:¶
| DaptomycinΔ 6 to 10 mg/kg IV every 24 hours |
Enterococci◊ | ||
Ampicillin susceptible | Ampicillin 2 g IV every 4 hours | Vancomycin (dosing as summarized above) |
Ampicillin resistant, vancomycin susceptible | Vancomycin (dosing as summarized above) | DaptomycinΔ 6 to 10 mg/kg IV every 24 hours Linezolid 600 mg IV (or orally) every 12 hours |
Ampicillin resistant, vancomycin resistant | DaptomycinΔ 6 to 10 mg/kg IV every 24 hours | Linezolid 600 mg IV (or orally) every 12 hours |
Enterobacteriaceae (examples include E. coli, Klebsiella spp, Enterobacter spp) | ||
ESBL negative | Ceftriaxone 2 g IV every 24 hours | Ciprofloxacin 400 mg IV every 12 hours |
ESBL positive | Imipenem 500 mg IV every 6 hours Meropenem 1 g IV every 8 hours Ertapenem 1 g IV every 24 hours | Ciprofloxacin 400 mg IV every 12 hours |
Pseudomonas spp§ | ||
Ceftazidime 2 g IV every 8 hours Cefepime 2 g IV every 8 hours Piperacillin-tazobactam 4.5 g IV every 6 hours¥ | Imipenem 500 mg IV every 6 hours Meropenem 1 g IV every 8 hours Ciprofloxacin 400 mg IV every 8 hours |
Do you want to add Medilib to your home screen?