Methimazole | |
Suppository | Dissolve 1200 mg methimazole in 12 mL of water, and add to 52 mL cocoa butter containing 2 drops of polysorbate (Span) 80. Stir mixture to form an emulsion, and pour into 2.6 mL suppository molds to cool.[1] |
Propylthiouracil | |
Suppository | Dissolve 200 mg of propylthiouracil in a polyethylene glycol base, and put into suppository tablets. |
Retention enema | Dissolve 8 to 12 (50 mg) tablets of propylthiouracil in 90 mL of sterile water. OR Dissolve 8 (50 mg) tablets of propylthiouracil in 60 mL of mineral oil enema (eg, Fleet mineral oil) or in 60 mL of sodium phosphates enema solution* (eg, Fleet enema phospho-soda).[2] For either enema preparation: Administer by Foley catheter inserted into the rectum, with balloon inflated to prevent leakage for 2-hour retention. |
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