Timing of prophylactic antibiotic administration and subsequent rates of SSIs
Timing of prophylactic antibiotic administration and subsequent rates of SSIs
Time of administration*
Percent with SSI
Odds ratio¶
95% CI
Early
3.8
4.3
1.8-10.4
Preoperative
0.6
1
-
Perioperative
1.4
2.1
0.6-7.4
Postoperative
3.3
5.8
2.4-13.8
SSI: surgical site infection. * "Early" denotes 2 to 24 hours before incision, "preoperative" 0 to 2 hours before incision, "perioperative" within 3 hours after incision, and "postoperative" more than 3 hours after incision. ¶ Odds ratio determined by logistic-regression analysis.
Data from: Classen DC, Evans RS, Pestotnik SL, et al. The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection. N Engl J Med 1992; 326:281.