Drug | Side effects* |
Brivaracetam¶ | Hypersensitivity reactions including bronchospasm and angioedema, leukopenia, neutropenia, psychosis |
Cannabidiol | Hypersensitivity reactions (including angioedema, erythema, and pruritus), suicidal ideation |
Carbamazepine | Agranulocytosis, aplastic anemia, SJS/TEN, hepatic failure, DRESS, dermatitis/rash, serum sickness, pancreatitis, lupus syndrome, hypogammaglobulinemia |
Cenobamate | QT interval shortening, DRESS/multiorgan hypersensitivity |
Clobazam | Respiratory depression, SJS/TEN, DRESS |
Eslicarbazepine | Prolonged PR interval, atrioventricular block, hyponatremia (rarely severe), SJS/TEN |
Ethosuximide | Agranulocytosis, SJS/TEN, aplastic anemia, hepatic failure, dermatitis/rash, serum sickness, drug-induced immune thrombocytopenia |
Felbamate | Aplastic anemia, liver failure |
Gabapentin | Multiorgan hypersensitivity, respiratory depression |
Lacosamide | Prolonged PR interval, atrioventricular block, multiorgan hypersensitivity, neutropenia |
Lamotrigine | SJS/TEN, DRESS/multiorgan hypersensitivity, aseptic meningitis, hypogammaglobulinemia, cardiac rhythm and conduction abnormalities |
Levetiracetam | SJS/TEN, anaphylaxis and angioedema, pancytopenia, psychosis, hypogammaglobulinemia |
Oxcarbazepine | SJS/TEN, DRESS/multiorgan hypersensitivity, agranulocytosis, pancytopenia, leukopenia |
Perampanel | Severe neuropsychiatric effects (eg, hostility, aggression) |
Phenobarbital | Agranulocytosis, SJS/TEN, hepatic failure, dermatitis/rash, serum sickness, connective tissue contractures (eg, Dupuytren), complex regional pain syndrome |
Phenytoin | Agranulocytosis, SJS/TEN, DRESS, aplastic anemia, hepatic failure, dermatitis/rash, serum sickness, adenopathy, pseudolymphoma, neuropathy, ataxia, lupus syndrome, hirsutism |
Pregabalin | Angioedema, hypersensitivity reactions, rhabdomyolysis, respiratory depression |
Primidone | Acute toxic reaction (sedation, dizziness, ataxia, nausea, and vomiting), agranulocytosis, SJS/TEN, hepatic failure, dermatitis/rash, serum sickness, connective tissue contractures (eg, Dupuytren) |
Rufinamide | SJS/TEN, DRESS, dermatitis/rash, shortened QT interval |
Stiripentol | Limited information: severe somnolence, marked weight loss, neutropenia and thrombocytopenia, suicidal ideation and behavior |
Tiagabine | SJS/TEN, nonconvulsive status epilepticus |
Topiramate | Acute myopia and glaucoma, kidney stones, oligohidrosis and hyperthermia (which primarily occur in children) |
Valproate | Agranulocytosis, SJS/TEN, aplastic anemia, hepatic failure, dermatitis/rash, serum sickness, pancreatitis, polycystic ovary syndrome, hypogammaglobulinemia |
Vigabatrin | MRI abnormalities, depression, weight gain |
Zonisamide | Rash, SJS/TEN, aplastic anemia, agranulocytosis, nephrolithiasis; acute myopia and secondary angle closure glaucoma, hyperammonemia and encephalopathy; in children, fever and hyperhidrosis |
DRESS: drug reaction with eosinophilia and systemic symptoms; MRI: magnetic resonance imaging; SJS: Stevens-Johnson syndrome; TEN: toxic epidermal necrolysis.
* As a class, antiseizure medications have been associated with an increased risk of suicidal ideation and suicidal behavior.
¶ Based upon limited experience from preapproval clinical trials.Do you want to add Medilib to your home screen?