Clinical scenario | Description | Examples and synonyms |
Nonclassic or early presentations of specific syndromes | Patients who present with features suggestive of a specific condition (eg, systemic lupus erythematosus [SLE], rheumatoid arthritis [RA], or systemic sclerosis) but have enough diagnostic uncertainty to preclude a diagnosis |
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Undifferentiated arthritis syndromes | Patients with inflammatory arthritis who do not clearly fit into specific subtypes of arthritis |
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Overlap syndromes | Patients who have systemic features that overlap 2 or more specific, recognized entities |
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Mixed connective tissue disease (MCTD) | Patients who have symptoms of multiple types of autoimmune conditions in the presence of high-titer anti-U1 ribonucleoprotein (RNP) antibodies |
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Undifferentiated connective tissue disease (USRD) | Patients with features suggestive of systemic autoimmune disease who do not otherwise fit into the above categories |
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