Primary tumor (T)* | |||
TX | Primary tumor cannot be assessed | ||
T0 | No evidence of primary tumor | ||
Tis | Carcinoma in situ | ||
T1 | Tumor 2 cm or less in greatest dimension with less than two high-risk features (see list of high-risk features below) | ||
T2 | Tumor greater than 2 cm in greatest dimension OR | ||
Tumor any size with two or more high-risk features | |||
T3 | Tumor with invasion of maxilla, mandible, orbit, or temporal bone | ||
T4 | Tumor with invasion of skeleton (axial or appendicular) or perineural invasion of skull base | ||
High-risk features for the primary tumor (T) staging | |||
Depth/invasion | >2 mm thickness | ||
Clark level ≥IV | |||
Perineural invasion | |||
Anatomic location | Primary site ear | ||
Primary site hair-bearing lip | |||
Differentiation | Poorly differentiated or undifferentiated | ||
Regional lymph nodes (N) | |||
NX | Regional lymph nodes cannot be assessed | ||
N0 | No regional lymph node metastases | ||
N1 | Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension | ||
N2 | Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension | ||
N2a | Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension | ||
N2b | Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension | ||
N2c | Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension | ||
N3 | Metastasis in a lymph node, more than 6 cm in greatest dimension | ||
Distant metastasis (M) | |||
M0 | No distant metastases | ||
MI | Distant metastases | ||
Anatomic stage/prognostic groups¶ | |||
Stage 0 | Tis | N0 | M0 |
Stage I | T1 | N0 | M0 |
Stage II | T2 | N0 | M0 |
Stage III | T3 | N0 | M0 |
T1 | N1 | M0 | |
T2 | N1 | M0 | |
T3 | N1 | M0 | |
Stage IV | T1 | N2 | M0 |
T2 | N2 | M0 | |
T3 | N2 | M0 | |
Any T | N3 | M0 | |
T4 | Any N | M0 | |
Any T | Any N | M1 |
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