Endocytoscopic image of esophageal squamous cell carcinoma

Endocytoscopic image of a squamous cell cancer of the esophagus (Panel A) and regular squamous epithelium (Panel B). Images were obtained after topical staining with methylene blue. Nuclei are clearly visible in both images. Whereas benign mucosa is characterized by regular nuclei, cancerous tissue shows irregularities with crowded nuclei and a clearly diminished nucleus to cell ratio.