Drug | Low dose (total daily dose) | Medium dose (total daily dose) | High dose (total daily dose)* |
Beclomethasone HFA Administer as 2 divided doses | 80 to 160 mcg | >160 to 320 mcg | >320 to 640 mcg |
40 mcg per actuation | 2 or 4 inhalations | ¶ | ¶ |
80 mcg per actuation | 2 inhalations | 4 inhalations | 6 or 8 inhalations |
Beclomethasone HFAΔ Administer as 2 divided doses | 100 to 200 mcg | >200 to 400 mcg | >400 to 800 mcg |
50 mcg per actuation | 2 to 4 inhalations | ¶ | ¶ |
100 mcg per actuation | 2 inhalations | 4 inhalations | 6 or 8 inhalations |
Budesonide DPI Administer as 2 divided doses | 180 to 360 mcg | >360 to 720 mcg | >720 to 1440 mcg |
90 mcg per actuation | 2 or 4 inhalations | ¶ | ¶ |
180 mcg per actuation | 2 inhalations | 4 inhalations | 6 or 8 inhalations |
Budesonide DPIΔ Administer low doses (ie, ≤400 mcg/day) once daily; administer higher doses (ie, >400 mcg/day) as 2 to 4 divided doses | 200 to 400 mcg | >400 to 800 mcg | >800 to 2400 mcg |
100 mcg per actuation | 2 to 4 inhalations | ¶ | ¶ |
200 mcg per actuation | 1 to 2 inhalations | 3 to 4 inhalations | ¶ |
400 mcg per actuation | 1 inhalation | 2 inhalations | 3 to 6 inhalations |
Ciclesonide HFA United States: Administer as 2 divided doses Australia, Europe, and elsewhere: Administer lower doses (ie, 160 to 320 mcg/day) once daily; administer 640 mcg dose as 2 divided doses | 160 mcg | 320 mcg | 640 mcg |
80 mcg per actuation | 2 inhalations | 4 inhalations | ¶ |
160 mcg per actuation | ◊ | 2 inhalations | 4 inhalations |
Ciclesonide HFAΔ Administer lower doses (eg, 100 to 400 mcg) once daily; administer 800 mcg dose as 2 divided doses | 100 to 200 mcg | >200 to 400 mcg | >400 to 800 mcg |
100 mcg per actuation | 1 to 2 inhalations | 3 to 4 inhalations | ¶ |
200 mcg per actuation | 1 inhalation | 2 inhalations | 3 to 4 inhalations |
Fluticasone propionate HFA Administer as 2 divided doses | 176 to 220 mcg | >220 to 440 mcg | >440 to 1760 mcg |
44 mcg per actuation | 4 inhalations | ¶ | ¶ |
110 mcg per actuation | 2 inhalations | 4 inhalations | ¶ |
220 mcg per actuation | ◊ | 2 inhalations | 4 to 8 inhalations |
Fluticasone propionate HFAΔ Administer as 2 divided doses | 100 to 250 mcg | >250 to 500 mcg | >500 to 2000 mcg |
50 mcg per actuation | 2 to 4 inhalations | ¶ | ¶ |
125 mcg per actuation | 2 inhalations | 4 inhalations | ¶ |
250 mcg per actuation | ◊ | 2 inhalations | 4 to 8 inhalations |
Fluticasone propionate DPI Administer as 2 divided doses | 100 to 250 mcg | >250 to 500 mcg | >500 to 2000 mcg |
50 mcg per actuation | 2 to 4 inhalations | ¶ | ¶ |
100 mcg per actuation | 2 inhalations | 4 inhalations | ¶ |
250 mcg per actuation | ◊ | 2 inhalations | 4 to 8 inhalations |
500 mcg per actuation (strength not available in United States) | ◊ | ◊ | 2 or 4 inhalations |
Fluticasone propionate DPI Administer as 2 divided doses | 110 mcg | 226 mcg | 464 mcg |
55 mcg per actuation | 2 inhalations | ¶ | ¶ |
113 mcg per actuation | ◊ | 2 inhalations | ¶ |
232 mcg per actuation | ◊ | ◊ | 2 inhalations |
Fluticasone furoate DPI Administer once daily NOTE: Inhaled fluticasone furoate has a greater anti-inflammatory potency per microgram than fluticasone propionate inhalers. Thus, fluticasone furoate is administered at a lower daily dose and used only once daily. | 50 mcg (by use of pediatric DPI, which is off-label in adolescents and adults) | 100 mcg | 200 mcg |
50 mcg per actuation | 1 inhalation | ¶ | ¶ |
100 mcg per actuation | ◊ | 1 inhalation | 2 inhalations |
200 mcg per actuation | ◊ | ◊ | 1 inhalation |
Mometasone DPI May administer lower doses (ie, 220 to 440 mcg/day) once daily; administer 880 mcg dose as 2 divided doses | 220 mcg | >220 to 440 mcg | >440 to 880 mcg |
110 mcg per actuation | 2 inhalations | ¶ | ¶ |
220 mcg per actuation | 1 inhalation | 2 inhalations | 4 inhalations |
Mometasone HFA Administer as 2 divided doses | 200 mcg | >200 to 400 mcg | >400 to 800 mcg |
100 mcg per actuation | 2 inhalations | 4 inhalations | ¶ |
200 mcg per actuation | ◊ | 2 inhalations | 4 inhalations |
Mometasone DPIΔ May administer lower doses (ie, 200 to 400 mcg/day) once daily; administer 800 mcg dose as 2 divided doses | 200 mcg | >200 to 400 mcg | >400 to 800 mcg |
200 mcg per actuation | 1 inhalation | 2 inhalations | ¶ |
400 mcg per actuation | ◊ | 1 inhalation | 2 inhalations |
DPI: dry powder inhaler; HFA: hydrofluoroalkane propellant metered dose inhaler.
* Evidence for additional improvement with dose increases >1000 mcg/day is limited.
¶ Select alternate preparation with higher mcg/actuation to improve convenience.
Δ Products shaded in light gray color are not available in the United States but are available widely elsewhere.
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