Pheochromocytoma* | Hyperparathyroidism | ||
Risk | RET codon mutation | Recommended age to begin annual screening for pheochromocytoma¶ | Recommended age to begin annual screening for hyperparathyroidismΔ |
Highest | 918 | 11 years | Not applicable |
High | 634, 883 | 11 years | 11 years |
Moderate | 533, 609, 611, 618, 620, 630, 666, 768, 790, 804, 891, 912 | 16 years | 16 years |
MEN2: multiple endocrine neoplasia type 2; MTC: medullary thyroid cancer; CT: computed tomography; MRI: magnetic resonance imaging; PTH: parathyroid hormone.
* Patients with MEN2 and a diagnosis of MTC (regardless of age) must have pheochromocytoma excluded prior to thyroidectomy.
¶ Screening test: free plasma metanephrines or normetanephrines, or 24-hour urinary metanephrines and normetanephrines. If biochemical results positive, adrenal imaging with CT or MRI.
Δ Screening test: serum calcium and, if elevated, PTH.Do you want to add Medilib to your home screen?