Acetaminophen-induced disease |
Arterial pH <7.3 (irrespective of the grade of encephalopathy) |
OR |
Grade III or IV encephalopathy AND |
Prothrombin time >100 seconds AND |
Serum creatinine >3.4mg/dL (301 µmol/L) |
All other causes of acute liver failure |
Prothrombin time >100 seconds (irrespective of the grade of encephalopathy) |
OR |
Any three of the following variables (irrespective of the grade of encephalopathy) |
1. Age <10 years or >40 years |
2. Etiology: non-A, non-B hepatitis, halothane hepatitis, idiosyncratic drug reactions |
3. Duration of jaundice before onset of encephalopathy >7 days |
4. Prothrombin time >50 seconds |
5. Serum bilirubin >18 mg/dL (308 µmol/L) |
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